منابع مشابه
GPR40: Good Cop, Bad Cop?
Since its deorphanization in 2003 (1,2), the fatty acid receptor GPR40 (FFAR1/FFA1) has drawn considerable attention as a potential therapeutic target for type 2 diabetes. Because fatty acids acutely amplify insulin secretion only in the presence of glucose, the discovery of a “drugable” cell surface receptor whose activation glucose-dependently enhances insulin release generated much interest ...
متن کاملp53 Good Cop/Bad Cop
Activation of the p53 transcription factor in response to a variety of cellular stresses, including DNA damage and oncogene activation, initiates a program of gene expression that blocks the proliferative expansion of damaged cells. While the beneficial impact of the anticancer function of p53 is well established, several recent papers suggest that p53 activation may in some circumstances act i...
متن کاملGood Cop, Bad Cop: Forcing Middleboxes to Cooperate
The original Internet architecture offered a clean contract to endpoints: packets sent will be delivered unmodified 1 or dropped when there is congestion. The proliferation of middleboxes has broken this simple contract to the point where the service the Internet provides to endpoints is entirely unpredictable: • Reachability depends on fields in the packet header and even the payload, as firew...
متن کاملDuality of lipid mediators in host response against Mycobacterium tuberculosis: good cop, bad cop
Lipid mediators play an important role in infection- and tissue injury-driven inflammatory responses and in the subsequent inhibition and resolution of the response. Here, we discuss recent findings that substantiate how Mycobacterium tuberculosis promotes its survival in the host by dysregulation of lipid mediator balance. By inhibiting prostaglandin E2 (PGE2) and enhancing lipoxin production,...
متن کاملInositol 1, 4, 5-trisphosphate Receptor in Cancer: Good Cop or Bad Cop?
Calcium signaling is very complex and intimately linked with cell survival and physiological form of cell death. Endoplasmic reticulum is the main intracellular storage of Ca and release of Ca is controlled by ER membrane localized IP3Rs and RYRs. These receptors regulate the transfer of Ca from ER to mitochondria via transport protein on mitochondrial membrane which regulates cellular bioenerg...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2010
ISSN: 1043-2760
DOI: 10.1016/j.tem.2009.12.004